H19 expression is robust in fetal hepatocytes but is sharply repressed in fully differentiated hepatocytes after birth.25 However, H19 expression is reactivated in hepatocellular carcinoma.26 Thus, we used Huh7 human hepatocellular carcinoma cells as an in vitro model system for our studies, because they mimic fetal hepatocytes in terms of H19 expression. Here, H19 is linked to hepatocellular carcinoma.