FZD8 and neoplasm: In addition to TNF signaling, many molecules involved in the wingless-type MMTV integration site family (WNT) signaling pathway were affected, including WNT3, WNT5A, WNT5B, WNT7B and FZD8. The functions of WNT signaling in cancer progression include cell proliferation, migration and tumor angiogenesis [55,56,57].