Considering the results regarding the characteristics of the anti-diabetic effect including lowered daily blood glucose and improvements of HbA1c and glucose intolerance in OGTT, although islet hypertrophy may have occurred by treatment with both [Zn(hmpt)2] and [Zn(hmps)2], it is likely that hyperinsulinemia did not occur in neither [Zn(hmpt)2] nor [Zn(hmps)2]-treated mice owing to the normalization of insulin secretion. Here, INS is linked to hyperinsulinism.