INS and type 2 diabetes mellitus: Insulin therapy in T2D (previously described as noninsulin dependent diabetes) relates to very old references.1–9 Some authors preferred the physiological approach with MDI and complemented the missing peak of postprandial endogenous insulin secretion (using small subcutaneous doses of short-acting insulin or insulin analog before each meal, adopted according to intensive self-monitoring).1–8 Other authors recommended a more comfortable regimen using once-daily injection of long-lasting insulin titrated according to a single value of fasting glycemia.