These states appear to be regulated by ZEB1: At least in some melanoma cell lines, ZEB1 overexpression induces resistance to BRAF/MEK inhibitors associated with a conversion of a MITFhigh into a MITFlow phenotype and with high expression of the nerve growth factor receptor CD271 (also termed NGFR, p75NTR) in resistant cells15,16. This evidence concerns the gene BRAF and melanoma.