Having established the effect of EV-DNA within monocytes, we wanted to establish whether the host response to the P. falciparum EV-DNA was indeed STING-dependent since it was previously reported that STING serves as an essential target for the development of malaria parasites8, yet the mechanism by which the parasites activate the pathway by inserting its DNA into immune cells while growing within RBCs was not determined. Here, STING1 is linked to malaria.