Knock-down of ERRα inhibited the tumor development on uterine endometrial cancer;26 ERRα is a marker of tamoxifen response and survival in triple-negative breast cancer;27 ERRα was also found to coordinate colon cancer cell proliferation and tumorigenic capacity with energy metabolism;28 WNT11 expression is induced by ERRα and beta-catenin, and acts in an autocrine manner to increase cancer cell migration29. The gene discussed is ESRRA; the disease is cancer.