TGFB1 and Hepatic fibrosis: This result was consistent with previous reports that Cur could promote the degradation of ECM by upregulating MMP-2 expression, and inhibit connective tissue growth factor expression, TGF-β/Smad signaling and proliferation of activated HSCs, resulting in reducing liver fibrosis (Zheng & Chen, 2006; Chen et al., 2014).