Furthermore, the protein expression of Notch1, HES1, and Bcl‐2 was reduced, and the protein level of c‐caspase3 was enhanced in MM cells silencing MALAT1, similarly, the regulation was strongly transformed after MM cells were transfected with pcDNA‐Notch‐1 (Fig. 6B and D). Here, HES1 is linked to Miyoshi myopathy.