Furthermore, the protein expression of Notch1, HES1, and Bcl‐2 was reduced, and the protein level of c‐caspase3 was enhanced in MM cells silencing MALAT1, similarly, the regulation was strongly transformed after MM cells were transfected with pcDNA‐Notch‐1 (Fig. 6B and D). This evidence concerns the gene NOTCH1 and Miyoshi myopathy.