Meta-analysis of 14 prior studies totaling 28,141 participants demonstrated that genetic polymorphisms of SLC2A9 and URAT1 are key regulators of urate homeostasis, as the inheritance of one predisposing variant of SLC2A9 or URAT1 significantly increases the risk for an individual to develop gout [3]. The gene discussed is SLC22A12; the disease is gout.