Although the serum tumor markers alpha-fetoprotein, lactate dehydrogenase, and β-human chorionic gonadotropin (β-HCG) are critical in diagnosing GCTs, determining the prognosis, and assessing the treatment outcome [1], these biomarkers were not predictors of a poor prognosis in patients with testicular cancer during their stay in the ICU. The gene discussed is AFP; the disease is testicular cancer.