As shown in Fig. S1, there are three groups without explicit preference of virus strain or cells, including (i) a large group of H1N1, H5N1, and H5N2 virus strains infecting A549 and Calu-3 cells; (ii) the H1N1/1918 strain with the original (gn37_8) and modified NS1 protein (gn37_7); and (iii) H9N2 avian influenza in A549 cells (gn31H9), and H1N1/PR8 in HBEC (gn19). This evidence concerns the gene IVNS1ABP and avian influenza.