At day 1, neither ISG20 nor JUN showed significant difference between DOCK5-wt and DOCK5-ko cells during the infections but VAMP5 was already significantly down-regulated by DOCK5-ko (H1N1: p = 0.0056, 0.1-fold change; H3N2: p = 0.0020, 0.19-fold change). Here, ISG20 is linked to infection.