To understand the functions of DOCK5 in influenza infection and defense, we performed a comprehensive functional analysis of the DOCK5-centered network conserved in a majority of the data sets, i.e., DOCK5-CCGS(7), through enrichment tests of known pathways and relevant gene signatures, as well as the previously identified differentially expressed gene sets including SRGs(7) and JTGs(7). The gene discussed is DOCK5; the disease is influenza.