Parallel to our observations, expression of mouse glutathione peroxidase (mGpx1) in fly photoreceptors retards rhabdomere loss in a Huntington’s disease/oxidative stress model.40 Like Cyt-b5, mGpx1 draws reducing power from cell metabolism and was the most neuroprotective of the antioxidants tested.40 Together, Gpx1 and Cyt-b5 may provide a powerful synergistic approach to counter lipid peroxidation in neurons exposed to strong oxidative stress during neurodegenerative disease. Here, GPX1 is linked to juvenile Huntington disease.