To verify that Pkm2 was deleted in tumors from Apcflox/flox;Pkm2flox/flox mice, we analyzed genomic DNA from Apcflox/flox;Pkm2+/+ and Apcflox/flox;Pkm2flox/flox colon tumors to confirm that PKM2 recombination had occurred (Fig. 2a). The gene discussed is PKM; the disease is colonic neoplasm.