H19 and Familial prostate cancer: In recent studies, lncRNA-H19 revealed two opposite function according to tumor types: one effect of lncRNA-H19 is as an oncogene in breast cancer [37], colorectal cancer [27], glioblastoma [38], and ovarian cancer [36]; the other one effect of lncRNA-H19 is as a tumor suppressor in hepatocellular carcinoma [39], nephroblastoma [41] and prostate cancer [40].