E2F1 and nonpapillary renal cell carcinoma: Our results indicated that lncRNA-H19 was up-regulated in ccRCC tissues and cells, and was involved in the migration and invasion of ccRCC by regulating miR-29a-3p/E2F1 pathway, implicating the potential application of lncRNA-H19 as an effective prognostic biomarker and novel therapeutic molecular target for ccRCC.