Pathologically, there is progressive degeneration of frontal and/or anterior temporallobe neurons, which is characterized by frontotemporal lobar degeneration(FTLD).14 It can bedivided into two major subtypes: FTLD with tau+ inclusions (FTLD-tau) and FTLD withubiquitin+ and TDP-43+ but tau-inclusions (FTLD-TDP). This evidence concerns the gene TARDBP and frontotemporal dementia.