Consensus opinion currentlyrecognizes five major pathological subtypes of FTLD (FTLD-tau, FTLD-TDP, FTLD-FUS,FTLD-UPS, and FTLD-no inclusions).19 The MAPT, PGRN and, recently,C9orf72 genes represent the three main genetic markersassociated with FTD. The gene discussed is MAPT; the disease is frontotemporal dementia.