APOE and Cognitive impairment: Theinappropriate situations include patient that fulfill the diagnosticcriteria for probable AD under typical age of onset, to determine thelevel of cognitive impairment, based solely on a positive family historyof dementia or APOE ε4 presentation, unconfirmed clinicalexamination of cognitive impairment, suspected autosomal mutationcarriers, asymptomatic individuals and nonmedical use such as legal,insurance coverage, or employment screening.