Recently, a newmutation (p.D348G) was found, a kindred with lower MND and respiratory failure, butwithout signs of cognitive impairment.25 Progressive hypoventilation has also been reported in the onlyfamily described to date with a homozygous MAPT mutation (p.S352L)although in the homozygous mutation, symptom onset occurred much earlier and bothsiblings died before five years of age.26 This evidence concerns the gene MAPT and mild neurocognitive disorder.