In FTD cohorts with more than 100 patients, MAPT mutations werefound in 3-11% of cases (9-38% among familial FTD cases, and 0-3% among sporadic FTDcases).9,12,16-21MAPT mutations cause disease with autosomal dominant inheritanceand penetrance greater than 95%.22 This evidence concerns the gene MAPT and frontotemporal dementia.