TARDBP and amyotrophic lateral sclerosis: To date, 34 pathogenic mutations have been reported, mainly in cases of familial andsporadic ALS.15 MostTARDBP mutations are missense, though insertions, deletions andnonsense mutations have been found in some cases.62 Cells with cytoplasmic inclusions immunostainedwith antibodies against TDP-43 typically do not exhibit TDP-43 in the nucleus (whereTDP-43 is found in normal cells).