Studies have shown inclusions immunoreactive to antibodies against ubiquilin 2 inspinal motor neurons and in the hippocampus,72 which appear to be co-localized with TDP-43 andFUS.75 Ubiquilin 2positive inclusions are not specific to the cases with mutations in this gene, alsobeing found in cases of ALS and FTD-MND without mutations inUBQLN2. Here, TARDBP is linked to amyotrophic lateral sclerosis.