PRNP and frontotemporal dementia: In fact, mutations inPSEN1 (presenilin 1) and PSEN2 (Presenilin 2)that cause autosomal dominant AD, have been found in families with the bvFTDphenotype.97 Dementia withfrontotemporal features has also been reported in mutations of other genes, such asin PRNP (prion protein), that cause genetic priondisease.98 The use of nextgeneration sequencing technologies to sequence gene panels, or even whole genomes orexomes, might be useful for identifying pathogenic mutations in familial FTD.