INS and Alzheimer disease: Glucose transporter 4 (GLUT4) is very important for glucose uptake and utilization inthe brain.38 Insulin stimulatesGLUT4 gene expression and protein trafficking from the cytosol to the plasmamembrane, modulating glucose uptake and utilization.38 Consequently, the regulation of neuronalmetabolism and the generation of energy needed for cognition and memory are linkedto insulin stimulation of GLUT4.38GLUT4 is abundantly expressed along with insulin receptors, in medial temporal lobestructures which are affected in AD pathology.