MAPT and argyrophilic grain disease: Clavaguera et al. showed that intracerebral injection of brain extracts containingaggregated tau, including AGD, induces tauopathy in tau-transgenic host mice, andthe induced tau lesions propagate systematically from the injection site to axonallyconnected areas suggesting neuronal uptake, transport and release of tau seeds.However, these mice did not show signs of neurodegeneration, suggesting that themolecular species responsible for propagation and neurotoxicity could bedifferent.78