Recent studiesdescribed two MAPT mutations causing pathological features consistent withAGD.20,72 A study published in 2008 demonstrated MAPT S305Imutation in a case with neuropathological diagnosis of AGD, while the most recentreport described S305S mutation in a Scandinavian family where two siblings hadneuropathological features resembling AGD. The gene discussed is MAPT; the disease is argyrophilic grain disease.