MAPT and Alzheimer disease: During abnormal conditions, the taucan become hyperphosphorylated and accumulate in NFT, resulting in a group ofdisorders known as tauopathies, the most common of which is AD.24,25,26 A new role ofthis tau has emerged, suggesting that tau might be involved in the regulation ofneuronal hyperexcitability.24,25 This was exemplified in anexperimental study testing the effect of tau reduction in non-transgenic adult miceby reducing endogenous tau levels using an antisense oligonucleotide infused intocerebrospinal fluid and subsequently analyzing the effects on behavior and inductionof seizures.