BCHE and Cognitive impairment: Cognitive disorders. These disorders are among the most commonlyoccurring sequelae in TBI and post-traumatic cholinergic deficits are thought tocontribute to the development of post-traumatic cognitive impairments.12 The study of Silver et al. (2006)– a randomized double-blind placebo-controlled study of a cholinesterase inhibitorin 157 post-TBI patients – showed no difference from placebo in both primarycognitive and secondary outcome measures.67