CBS and mild neurocognitive disorder: These mutations are present incases of sporadic or familial FTLD (with or without MND) and in cases of AmyotrophicLateral Sclerosis (ALS).61,62 Borroni et al., 2010,62 evaluated the role ofTARDBP mutations in 252 FTLD consecutive patients (153 bvFTD,15SD, 22PNFA, and 62 CBS) and found only five mutations in patients with bvFTD andFTD-MND.