TARDBP and amyotrophic lateral sclerosis: In 2006, Neumann et al.18demonstrated that the TAR-DNA binding protein 43 (TDP-43), a 43kDa protein, is themost common protein linked to ubiquitin in cases previously classified as FTLD-U, aswell as the majority of sporadic (and some familial) amyotrophic lateral sclerosis(ALS).