The clinicaldiagnosis of VP is supported by radiological studies which have evolved over thelast two decades from computed tomography (CT) to magnetic resonance imaging (MRI)and dopamine transporter single photon-emission CT scan (DAT-SPECT).1 Although the clinical andradiological features of VP are widely known, no consensus exists with regard to itspathophysiology, diagnostic criteria and treatment. The gene discussed is SLC6A3; the disease is variegate porphyria.