Moreover, thesesymptoms appear not only to coexist but also influence each other in relation toevolution.7 Other authorsevaluating the prevalence of depression and anxiety using the BDI and the inventoryof Spielberger's State-Trait, respectively, in patients with headache ofnontraumatic origin and PTH have found similar alterations between groups.19 The gene discussed is PTH; the disease is Headache.