In general, clinical use of the genetic test for APOE with predictive intent inasymptomatic individuals is not recommended because the presence of theε4 allele is not necessary nor sufficient to reach a diagnosis ofAD.100,101 Family history on the otherhand, represents a better predictor of risk for AD.101 Empirically, first-degree relatives of asingle individual with AD have a 20-25% chance of developing the disease duringtheir lifetime compared to 10% for individuals with no family history of thedisease.93 Here, APOE is linked to Alzheimer disease.