APOE and Alzheimer disease: The presence of the ε4 allele of the APOE is not sufficiently specific forinclusion in the new criteria for probable AD with a high degree ofcertainty.62Clinico-pathologic series in which the genotyping of the APOE was estimated werenot favorable for introduction of the test for the gene in clinical practice.The sensitivity and specificity of clinical diagnosis alone were 93% and 55%,respectively, whereas for the genotyping of the APOE this was 68% and 65%,respectively.102