Increased corticosterone levels induced by chronic immobilization stress or by acuteadministration of dexamethasone are associated with both acceleratedAβ plaque formation and tau protein phosphorylation,once again showing a relationship between AD neuropathology biomarkers and stresshormones.59,84 Additionally, recent evidencelinks GCs, Aβ formation and neuronal apoptosis after chronicadministration of high doses of dexamethasone in mice models of AD.85 This evidence concerns the gene MAPT and Alzheimer disease.