The neuropathology of AD is characterized by extracellular plaque formation byβ-amyloid (Aβ) deposition and intracellularneurofibrillary tangles by aggregates of protein tau hyperphosphorylation in thecortex and hippocampus.80Alterations in hippocampus plasticity and neurogenesis have also been reported in ADsubjects.81,82. This evidence concerns the gene MAPT and Alzheimer disease.