APOE and Alzheimer disease: The presence of theepsilon4 allele ofapolipoprotein E (APOE), a risk factor for sporadic AD, has also been associatedwith nitrite oxidative stress markers.94 Interestingly, recent findings have shown that increases inlipid peroxidation were three-fold greater in stressed AD mice compared tounstressed controls, and these elevations in oxidative stress markers decrease afterpharmacological blocking of corticosterone.84