Silent stroke has been associatedwith increased C-reactive protein and interleukin-6, coronary artery disease, bodymass index, and alcohol consumption, as well as overt stroke, dementia, depression,and aspiration pneumonia.39 Therelationship of silent brain infarction, body mass index, coronary artery diseaseand cognitive status deserves further in-depth investigation in a Braziliansample. The gene discussed is IL6; the disease is major depressive disorder.