SELP and cardiovascular disorder: Recent evidence also suggests that the cell adhesion moleculeP-selectin (SELP) genotypes, which moderate circulating levels of P-selectin,may contribute to the adverse vascular processes that seem to promote cognitiveimpairment in individuals with cardiovascular disease.53 In addition, the recent hypothesis that asubset of VCI patients could have an inflammatory process with disruption andincreased permeability of the BBB should be further investigated in order todetect the clinical spectrum, associated risk factors, and potential biologicalmarkers in the CSF of this subgroup of VCI (27).