In particular, the adjusted hazardratios (HR) of incident dementia, compared to individuals with neither strokenor APOE 4, were 1.33 (95% CI 0.73-2.43) for stroke alone, 2.06 (95% CI1.42-2.99) for APOE 4 alone, and 2.57 (95% CI 1.11-5.94) for both stroke andAPOE 4. This evidence concerns the gene APOE and dementia.