However, this has been proven inrandomized-controlled trials only for hypertension.40-44 Theeffects of antihypertensive treatment on cognitive function was evaluated in 326non-demented community-dwelling participants over the age of 70 years in theWomen’s Health and Aging Study II.45 The use of angiotensin-converting enzyme inhibitors(ACE-Is) or diuretics, was associated with reduced incidence of impairment ofboth global and domain-specific cognition in elderly women, thus helpingdelaying the progression towards dementia. The gene discussed is ACE; the disease is hypertensive disorder.