Protective mechanisms involved in the association of alcohol consumption withdecrease in risk of dementia and vascular alterations, include increase of HDLand decrease of LDL, resulting in lowering of risk due to cholesterol; reductionof insulin resistance and increase in insulin sensitivity; reduction of bloodhomocysteine; decrease of systemic arterial pressure; reduction in plateletaggregation and fibrinogen levels, with increased fibrinolysis; and reduction ininflammatory markers. Here, INS is linked to dementia.