GSK3B and Alzheimer disease: One interestingstudy in human leukocytes showed that peripheral GSK3β activity is increasedin AD.55 Such converging evidencesupport the “GSK3β hypothesis” in AD,56 according to which, the deregulation of GSK3βmetabolism leading to increased activity is an early pathological event in thepathophysiology of AD, triggering several downstream events culminating in increasedproduction of Aβ and TAU hyperphosphorylation.