In their own case series Braak and colleagues classified most of the AGD cases ashaving AD ranging from stage from I to IV.18 However, the apparently small percentage of AGs in advancedstages of AD must be interpreted with care, as the substantialphospho-tau-immunoreactive pathology in such cases may incrementally hamper thevisualization of AGs. The gene discussed is MAPT; the disease is Alzheimer disease.