We studied 12 AD patients (6 women), average age 75.42 (6.22) with 9.58 (5.6)years education in use of stable doses of cholinesterase inhibitors.Cognitive performance was evaluated using Mini-Mental State Examination(MMSE) and Alzheimer ́s Disease Assessment Scale-cognitive (ADAS-Cog).Caregivers responded to Neuropsychiatric Inventory (NPI) and FunctionalActivities Questionnaire (FAQ) at initial evaluation (T1), and after 8months of rehabilitation program (T2). The gene discussed is BCHE; the disease is early-onset autosomal dominant Alzheimer disease.