Strategy combining orientation interventions (clock, calendar, day's schedule chart, visual and hearing support, language interpreters); familiarity interventions with objects and family members; physiotherapy; hip protectors, and nutritional supplements with the prescription of cholinesterase inhibitors as needed and restriction of the use of neuroleptics provided more pronounced and rapid reduction in the severity of delirium and cognitive improvement after discharge.30 The gene discussed is BCHE; the disease is delirium.