APOE and Alzheimer disease: This allele is considered to be responsible for 50% of late-onset Alzheimer dementia (AD).49 In Colombia, an association between APOE4 and late-onset AD with a risk of 5.1% has been reported;50 currently, we are evaluating the association of APOE4 with cognitive impairment among the subjects from the present study sample, and the association of their cardiometabolic risk factors are discussed in a recent paper.51