The ALS-FTD case showed positive phospho-TDP-43 neuronal cytoplasmic inclusions (NCI) in all regions studied (frontal, parietal, temporal, occipital, amygdala, hippocampus, entorhinal cortex, mesencephalon, pons and medulla oblongata) (Figure 1), while the FTD case presented immunoreactivity in all regions except the pons and medulla oblongata (Figure 2). This evidence concerns the gene TARDBP and frontotemporal dementia.