Besides extracellular deposits of β-amyloid, in AD there is formation ofintracellular neurofibrillary tangles of hyperphosphorylated tau protein andconsequent loss of neuronal synapses.12 Tau is a family of phosphoproteins39 associated with microtubules, particularly inneurons40 located mainlyin the axonal cone and axonal endings of these cells.39 Here, MAPT is linked to Alzheimer disease.