MAPK8 and Insulin resistance: Type 2 diabetes is characterized by hyperglycemia, decreased production of insulin orits availability, and insulin resistance.57 In this context, intraperitoneal injections ofAβ1-42 promoted hyperglycemia and insulin resistance in vivovia JAK2 in mice.88 In the study,insulin resistance appeared to be mediated by the activation of JNK, which inducedinhibition of insulin signaling.89This data was obtained by intracerebroventricular injection of Aβ oligomersin non-human primates and through in vitro hippocampal neuron investigation.