The increase in proinflammatory cytokinesinduces a chronic inflammatory process and reactive oxygen species (ROS)production.72,73 Oxidative stress promotes theactivation of molecules such as JNK and thus insulin resistance.74 Insulin resistance and chronicperipheral hyperinsulinemia implies down-regulation of insulin transport to thebrain, possibly inducing insulin deficiency in it.75 The gene discussed is MAPK8; the disease is Insulin resistance.