MAPT and Alzheimer disease: AD transgenic models submitted to a high-fat diet showed increases inβ-amyloid and tau protein as well as activated astrocytes in mice braincortex.81Senescence-accelerated mice treated with a high-fat diet also showed an increase inβ-amyloid and tau protein levels.79 By contrast, calorie restriction has been shown to reducethe deposition of β-amyloid in both elderly mice82 and transgenic models of AD.83 These data suggest a closerelationship between type 2 diabetes and AD.