Forinstance, SD cases may develop features of bv-FTD, and there is also an overlapbetween FTD and other neurodegenerative diseases such as progressive supranuclearpalsy (PSP), and corticobasal degeneration (CBD) and ALS.16 TAR DNA-binding protein 43 (TDP-43), whose gene islocated on chromosome 1, has been linked to the pathogenesis of FTD and ALS. The gene discussed is TARDBP; the disease is supranuclear palsy, progressive, 1.