MAPT and early-onset autosomal dominant Alzheimer disease: For example, despite the specificity forsCJD, periodic sharp wave complexes were recently reported in a case of VGKCencephalitis7 and can bepresent in patients with other etiologies (i.e. Alzheimer disease and vasculardementia).18 The utilityof CSF biomarkers such as 14-3-3, total tau (t-tau), neuron specific enolase (NSE)is very controversial, as these proteins are not prion specific and the test doesnot identify prions.