BDNF and Huntington disease: All these regions supply thestriatum with BDNF.86,87 In HD, the deficit of BDNF in thestriatum may be due to reduced BDNF gene transcription in the cerebral cortex orreduced BDNF vesicle transport (or both).88,89 The decrease inBDNF expression observed in HD impairs dopaminergic neuronal function, which may beassociated with HD motor disturbances.