,7,38,39 Patholo gical processes most widely investigated through biomarkers are: brainamyloidosis (by decreased b-amyloid peptide in cerebrospinal fluid and PET-CT withpositive ligands for b-amyloid - for example Pittsburgh compound B, PiB) andneurodegeneration (by elevated total tau and phosphorylated tau proteins in thecerebrospinal fluid, cortical atrophy on structural magnetic resonance imaging, MRI, anddecreased glycolytic metabolism in 18F-fluorodeoxyglucose PET-CT).1 This evidence concerns the gene MAPT and Cerebral cortical atrophy.