Another cellular change related to BLP- and GRPR-elicited signaling described infibroblasts from patients with AD, is a reduced number of BB receptors.24 This interesting finding raisesthe possibility that decreased neuronal GRPR density, leading to impaired BLPfunction in the brain of AD patients, is related to neurodegeneration and memoryloss associated with the disease. This evidence concerns the gene GRPR and Alzheimer disease.