RETN and obesity due to melanocortin 4 receptor deficiency: It is not known however which adipose tissue depot, visceral (VAT) or subcutaneous (SAT) plays a dominant role in the synthesis and secretion of adiponectin and resistin in health and in obesity, because analyses of the ADIPQ and RETN expression (encoding adiponectin and resistin, respectively) in human adipose tissue were performed on the mRNA level [18–20].