CD8A and infection: Microflora has been shown to influence the naïve CD8 T cell repertoire (23), and while our data did not show a correlation between the size of the Ag-experienced compartment prior to infection and size of the CD8 T cell response following infection, further exploration of how commensal flora impacts naïve CD8 T cell repertoire and how this might influence the CD8 T cell response to infection in outbred mice is warranted.