Again, differences in amount of inflammatory cytokines (IFN-γ and IL12) elicited in response to LM infection and pathogen load were seen between inbred and outbred mice (Figure S5 in Supplementary Material), but differences in magnitude of effector CD8 T cell responses in individual outbred mice appeared unlikely to be caused by differences in infection or amount of inflammation elicited in response to infection in individual outbred mice. The gene discussed is CD8A; the disease is infection.