MPO and cystic fibrosis: Since PA3177 expression was also induced by contact with human macrophages, and given the fact that infected CF lungs bear an unusual high phagocytic burden and thus severely increased levels of HClO-generating MPO enzyme (Van Der Vliet et al., 2000; Downey et al., 2009), we can imagine an implication of this DGC in the development of persistent P. aeruginosa strains during chronic infections.