Furthermore, as far as fibrinolysis is concerned, chronic inflammation, abdominal obesity, and IR all increase plasminogen activator inhibitor-1 (PAI-1) production, so reducing plasminogen conversion and leading to a hypofibrinolytic state (Alessi and Juhan-Vague, 2008; Suehiro et al., 2012). The gene discussed is SERPINE1; the disease is Abdominal obesity.