SCN11A and neuropathic pain: Studies have proved that inflammatory mediators released from injured and inflammatory cells modulate Nav1.9 currents to maintain inflammation-induced hyperalgesia (Baker et al., 2003; Priest et al., 2005; Amaya et al., 2006; Ostman et al., 2008), which probably supports a role for Nav1.9 in inflammatory and neuropathic pain.