Furthermore, PD-1+ Tim-3+ cells among T-cells were significantly higher in tumor tissues than those in blood (15.47% vs. 3.17%, p < 0.0001, Fig. 3g for CD4+; 18.2% vs. 1.45%, p < 0.0001, Additional file 2: Figure S2G for CD8+) and paraneoplastic tissues (15.47% vs. 6.64%, p < 0.0001, Fig. 3g for CD4+; 18.2% vs. 3.87%, p < 0.0001, Additional file 2: Figure S2G for CD8+). Here, HAVCR2 is linked to neoplasm.