Additionally, PD-1-PD-L1 blockade in combination with Tim-3-Tim-3-L blockade further enhanced the capacity of tumor-infiltrating CD4+ T-cells to produce IFN-γ as compared with anti-PD-1-mAbs group (p = 0.0398) or anti-Tim-3-mAbs group (p = 0.0027). This evidence concerns the gene CD4 and neoplasm.