Given that PI3Kα/Akt signaling (specific PI3Kα, Akt1 and Akt2 isoforms) mediate Wnt5a-induced the migration of osteosarcoma cells [5, 6], we propose that PI3Kα/Akt act as the downstream of Wnt5a and ROR2. This evidence concerns the gene ROR2 and osteosarcoma.