Fard-Esfahani et al. in 2005, who examined 30 patients with clinical possible FH, identified one novel mutation in exon 4 of the LDLR p.(Gly445Cy) using the PCR-single-strand conformation polymorphism (PCR-SSCP) method18, while another study used PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) and PCR-SSCP methods, where no mutations were reported either in the promoter or coding region of LDLR or in exon 26 of APOB16,17. Here, LDLR is linked to familial hyperaldosteronism.